Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …

Here we critically evaluate the role of elevated hematocrit as the principal determinant of
thrombotic risk in polycythemia and erythrocytosis, defined by an expansion of red cell mass …

Stroke is common in children with sickle cell disease and results from an imbalance in
oxygen supply and demand. Cerebral blood flow (CBF) is increased in patients with sickle …

Purpose T2 MRI oximetry can noninvasively determine oxygen saturation (Y) but requires
empirical MR calibration models to convert the measured blood transverse relaxation (T2b) …

Cerebrovascular reactivity can be measured as the cerebrovascular flow response to a
hypercapnic challenge. The many faceted responses of cerebral blood flow to combinations …

Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell
anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress …

Severe chronic anemia is an independent predictor of overt stroke, white matter damage,
and cognitive dysfunction in the elderly. Severe anemia also predisposes to white matter …

Anemia is the most common blood disorder in the world. In patients with chronic anemia,
such as sickle cell disease or major thalassemia, cerebral blood flow increases to …

Purpose Gadolinium‐based dynamic susceptibility contrast (DSC) is commonly used to
characterize blood flow in patients with stroke and brain tumors. Unfortunately, gadolinium …

Patients with sickle cell anemia (SCA) experience cerebral metabolic stress with an increase
in oxygen extraction fraction (OEF) to compensate for reduced oxygen carrying capacity due …