Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of
several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease …

There are multiple sources of reactive oxygen species (ROS) in the cell. As a major site of
ROS production, mitochondria have drawn considerable interest because it was recently …

Background Mitochondrial dysfunction and defects in oxidative metabolism are a
characteristic feature of many chronic illnesses not currently classified as mitochondrial …

Objective—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …

Parkinson's disease is the second most common neurodegenerative movement disorder;
however, its etiology remains elusive. Nevertheless, in vivo observations have concluded …

Mitochondria are important for providing cellular energy ATP through the oxidative
phosphorylation pathway. They are also critical in regulating many cellular functions …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs) is classified by the World
Health Organization as a disorder of the central nervous system. ME/cfs is an neuro-immune …

There is substantial agreement that the unbalance between oxidant and antioxidant species
may affect the onset and/or the course of a number of common diseases including …

Neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases
have high prevalence among the elderly. Many strategies have been established to alleviate …