Rapid advances in the field of epigenetics have facilitated the development of novel
therapeutics targeting epigenetic mechanisms that are hijacked by cancer cells to support …

As the backbone of oncological treatments, systemic chemotherapy is still one of the main
pawns in cancer care, alone or in combination with newer targeted agents. All …

Platinum (Pt) compounds such as oxaliplatin are among the most commonly prescribed anti-
cancer drugs. Despite their considerable clinical impact, the molecular basis of platinum …

Lung and colorectal cancers are among the leading causes of death from cancer worldwide.
Although topotecan (TPT), a topoisomerase1 inhibitor, is a first-and second-line drug for …

More than a century ago, independent groups raised the possibility of using bacteria to
selectively infect tumours. Such treatment induces an immune reaction that can cause …

2 High-Dose Conventional Chemotherapy Page 1 2 High-Dose Conventional Chemotherapy
KELVIN KOW* Ethos Veterinary Health, Portsmouth, New Hampshire, USA Introduction: History …

Many autoimmune diseases confer a higher risk of cancer on patients compared to the
general population. A controversial factor tying autoimmune diseases to malignancy is harm …

ABSTRACT CCNU (1‐[2‐chloroethyl]‐3‐cyclohexyl‐1‐nitrosurea), lomustine, is an oral
alkylating agent in the nitrosourea subgroup. The dose‐limiting toxicity of CCNU is …

Abstract Background Classical Hodgkin Lymphomas (HL) are a unique malignant growth
with an excellent initial prognosis. However, 10–30% of patients will still relapse after …

Background Capecitabine is an oral prodrug of the active metabolite 5-fluorouracil, which
has been used effectively in human colorectal, head and neck, and mammary carcinomas …