Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its
negative impact and thus results in anxiety. Here, we focus the broad literature on the …

Neuropsychological approaches represent an important avenue for identifying susceptibility
and resiliency factors relating to the development and maintenance of posttraumatic stress …

In the regulation of behavior, the role of GABA neurons has been extensively studied in the
circuit of fear, where GABA interneurons play key parts in the acquisition, storage and …

Emotional problems figure prominently in many clinical conditions. Recent efforts to explain
and treat these conditions have emphasized the role of emotion dysregulation. However …

A striking neurochemical form of compartmentalization has been found in the striatum of
humans and other species, dividing it into striosomes and matrix. The function of this …

This review summarizes evidence of dysregulated reward circuitry function in a range of
neurodevelopmental and psychiatric disorders and genetic syndromes. First, the …

Over the past 25 years, considerable progress has been achieved in treating adult
psychiarric disorders (eg, Butler, Chapman, Forman, & Beck, 2006). Despite these …

“Distress disorders,” which include generalized anxiety disorder and major depression are
often highly comorbid with each other and appear to be characterized by common …

Neurodevelopmental changes over the lifespan, from childhood through adulthood into old
age, have important implications for the onset, presentation, course, and treatment of anxiety …

BackgroundThe mechanisms that contribute to emotion dysregulation in anxiety disorders
are not well understood. Two common disorders, generalized anxiety disorder (GAD) and …