Abstract Objective To describe PCORnet, a clinical research network developed for patient-
centered outcomes research on a national scale. Study Design and Setting Descriptive …

Importance Determining the right dosage of aspirin for the secondary prevention treatment of
atherosclerotic cardiovascular disease (ASCVD) remains an unanswered and critical …

In 2015, we provided an overview of the use of digital technologies in clinical trials, both as a
methodological tool and as a mechanism to deliver interventions. At that time, there was …

Background Pragmatic trials are gaining popularity as a cost-effective way to examine
treatment effectiveness and generate timely comparative evidence. Incorporating …

Background Frailty is rarely assessed in clinical trials of patients who receive dual
antiplatelet therapy (DAPT) after percutaneous coronary intervention. This study investigated …

Objective To empirically explore how pragmatic clinical trials (PCTs) that used real-world
data (RWD) assessed study-specific fitness-for-use. Methods We conducted interviews and …

Importance Community Paramedicine at Clinic (CP@ clinic) is a chronic disease prevention
program that decreases 911 calls for emergency medical services, but its wider system …

Abstract PCORnet, the National Patient-Centered Clinical Research Network, provides the
ability to conduct prospective and observational pragmatic research by leveraging …

Background: We aimed to understand the effects of aspirin dose on outcomes in patients
with peripheral artery disease (PAD) as well as their participation in a pragmatic randomized …

Background: The integration of data from disparate sources could help alleviate data
insufficiency in real-world studies and compensate for the inadequacies of single data …