Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to
contribute to diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent …

Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney
disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic …

Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting
in elevated cost for public health systems. DN is the main cause of chronic kidney disease …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …