The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

Lysophosphatidic acid (LPA) is a potent lipid mediator with various biological functions
mediated through six G protein–coupled receptors (GPCRs), LPA1–LPA6. Previous studies …

Background: Multiple sclerosis (MS) is characterized by a combination of inflammatory and
demyelination processes in the spinal cord and brain. Conventional drugs generally target …

Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR 1-6) and regulates various
cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies …

Abstract Lysophosphatidic acid (LPA, 1-acyl-2-hemolytic-sn-glycerol-3-phosphate) extracted
from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …

Feeding cuprizone (CPZ) to mice causes demyelination and reactive gliosis in the central
nervous system (CNS), hallmarks of some neurodegenerative diseases like multiple …

Multiple Sclerosis (MS) is a debilitating autoimmune disease often accompanied by severe
chronic pain. The most common type of pain in MS, called neuropathic pain, arises from …

A number of membrane lipid-derived mediators play pivotal roles in the initiation,
maintenance, and regulation of various types of acute and chronic pain. Acute pain …