Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

Background Microalbuminuria is an early sign of kidney disease in people with diabetes and
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …

Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

In its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent.
Significant reduction of the kidney function is the first obvious sign of disease. If diagnosed …

Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney
disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD …

Background How to select variables and identify functional forms for continuous variables is
a key concern when creating a multivariable model. Ad hoc 'traditional'approaches to …

Capillary electrophoresis (CE) offers fast and high‐resolution separation of charged
analytes from small injection volumes. Coupled to mass spectrometry (MS), it represents a …