The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Identification of ethanol's (EtOH) primary molecular brain targets and determination of their
functional role is an ongoing, important quest. Pentameric ligand‐gated ion channels, that is …

Using a well-established model of ethanol dependence and relapse, this study examined
adaptations in glutamatergic transmission in the nucleus accumbens (NAc) and their role in …

Neuroimaging studies of patients with chronic pain have shown that neurotransmitter
abnormalities, including increases in glutamate and decreases in GABA, could be …

While research on the actions of ethanol at the GABAergic synapse has focused on
postsynaptic mechanisms, recent data have demonstrated that ethanol also facilitates GABA …

Trauma-induced damage to the orbitofrontal cortex (OFC) often results in behavioral
inflexibility and impaired judgment. Human alcoholics exhibit similar cognitive deficits …

Monitoring changes in chemical concentrations over time in complex environments is
typically performed using sensors and spectroscopic techniques. Another approach is to …

Background Many general anesthetics are thought to produce a loss of wakefulness, in part,
by enhancing gamma-aminobutyric acid (GABA) neurotransmission. However, GABAergic …

J. Neurochem.(2011) 118, 571–580. Abstract The oral part of the pontine reticular formation
(PnO) is a component of the ascending reticular activating system and plays a role in the …

An off-line in vivo neurochemical monitoring approach was developed based on collecting
nanoliter microdialysate fractions as an array of “plugs” segmented by immiscible oil in a …