Signal transducer and activator of transcription (STAT) 3 and STAT5 are important
transcription factors that are able to mediate or even drive cancer progression through …

Granulocyte colony-stimulating factor (G-CSF) has been used in the clinic for more than 2
decades to treat congenital and acquired neutropenias and to reduce febrile neutropenia …

Tumourigenesis caused by the Bcr/Abl oncoprotein is a multi‐step process proceeding from
initial to tumour‐maintaining events and finally results in a complex tumour‐supporting …

Most neurological diseases are associated with chronic inflammation initiated by the
activation of microglia, which produce cytotoxic and inflammatory factors. Signal transducers …

During B lymphopoiesis, recombination of the locus encoding the immunoglobulin κ-chain
complex (Igk) requires expression of the precursor to the B cell antigen receptor (pre-BCR) …

Persistent activation of the Hedgehog (HH)/GLI signaling pathway has been implicated in
the development of a number of human cancers. The GLI zinc finger transcription factors act …

STAT5 proteins are constitutively activated in malignant cells from many patients with
leukemia, including the myeloproliferative neoplasms (MPNs) chronic myeloid leukemia …

The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …

Stat5 is constitutively activated in many human cancers affecting the expression of cell
proliferation and cell survival controlling genes. These oncogenic functions of Stat5 have …

Abstract CASTRO-VALE, I., EFC van Rossum, JC Machado, R. Mota-Cardoso and D.
Carvalho. Genetics of glucocorticoid regulation and posttraumatic stress disorder—What do …