Background A diagnosis of Lamin proteins A and C cardiomyopathy (LMNA-CM) not only
impacts disease prognosis, but also leads to specific guideline-recommended treatment …

Background The genetic variants of LMNA cause an array of diseases that often affect the
heart. LMNA-related cardiomyopathy exhibits high-penetrance and early-onset phenotypes …

Nuclear envelope (NE) ruptures are emerging observations in Lamin-related dilated
cardiomyopathy, an adult-onset disease caused by loss-of-function mutations in Lamin A/C …

Mutations in the LMNA gene (encoding lamin A/C proteins) cause several human cardiac
diseases, including dilated cardiomyopathies (LMNA-DCM). The main clinical risks in LMNA …

Mutations in the nuclear Lamin A/C gene (LMNA) cause diverse degenerative disorders,
including malignant dilated cardiomyopathy in adults. A prevailing hypothesis postulates …

Cardiac laminopathies encompass a wide range of diseases caused by defects in nuclear
envelope proteins, including cardiomyopathy, atrial and ventricular arrhythmias and …

LMNA-related dilated cardiomyopathy (LMNA-DCM) is one of the most severe forms of
DCM. The incomplete understanding of the molecular disease mechanisms results in …

Congenital heart disease (CHD) is a leading cause of birth defect-related death. Despite
significant advances, the mechanisms underlying the development of CHD are complex and …

Mutations in the LMNA gene (encoding lamin A/C proteins) cause several human cardiac
diseases, including dilated cardiomyopathies (LMNA-DCM). The main clinical risks in LMNA …

Background: Cardiolaminopathies, heterogeneous and complex manifestations of LMNA
gene mutations, are characterized by the frequent occurrence of dilated cardiomyopathy …