Future perspectives for treating patients with geographic atrophy

A Loewenstein, O Trivizki - Graefe's Archive for Clinical and Experimental …, 2023 - Springer
Purpose Geographic atrophy (GA) is a late-stage form of age-related macular degeneration
(AMD) characterized by the expansion of atrophic lesions in the outer retina. There are …

Treating patients with geographic atrophy: are we there yet?

B Antonio-Aguirre, JF Arevalo - International Journal of Retina and …, 2023 - Springer
Geographic atrophy (GA) is a progressive degenerative disease that significantly contributes
to visual impairment in individuals aged 50 years and older. The development of GA is …

Geographic atrophy growth is strongly related to lesion perimeter: unifying effects of lesion area, number, and circularity on growth

LL Shen, M Sun, A Ahluwalia, BK Young, MM Park… - Ophthalmology …, 2021 - Elsevier
Purpose To investigate the underlying reason for the previously observed impact of baseline
lesion size, number, and circularity on geographic atrophy (GA) growth rate. Design …

Classification and growth rate of chorioretinal atrophy after voretigene neparvovec-rzyl for RPE65-mediated retinal degeneration

N Bommakanti, BK Young, RA Sisk, AM Berrocal… - Ophthalmology …, 2024 - Elsevier
Purpose Classify the appearance and quantify the growth rate of chorioretinal atrophy in
patients who received voretigene neparvovec-rzyl (VN) for RPE65-mediated retinal …

Long-term natural history of visual acuity in eyes with choroideremia: a systematic review and meta-analysis of data from 1004 individual eyes

LL Shen, A Ahluwalia, M Sun, BK Young… - British Journal of …, 2021 - bjo.bmj.com
Background/aims Best-corrected visual acuity (BCVA) is the most common primary endpoint
in treatment trials for choroideremia (CHM) but the long-term natural history of BCVA is …

Relationship of topographic distribution of geographic atrophy to visual acuity in nonexudative age-related macular degeneration

LL Shen, M Sun, A Ahluwalia, BK Young, MM Park… - Ophthalmology …, 2021 - Elsevier
Purpose To investigate the topographic distribution of geographic atrophy (GA) and to
identify an anatomic endpoint that correlates with visual acuity (VA) in eyes with GA. Design …

Progression of cRORA (complete RPE and outer retinal atrophy) in dry age-related macular degeneration measured using SD-OCT

O Shmueli, R Yehuda, A Szeskin… - … Vision Science & …, 2022 - tvst.arvojournals.org
Purpose: The purpose of this study was to evaluate the long-term rate of progression and
baseline predictors of geographic atrophy (GA) using complete retinal pigment epithelium …

[HTML][HTML] Progression dynamics of early versus later stage atrophic lesions in nonneovascular age-related macular degeneration using quantitative OCT biomarker …

LM Coulibaly, GS Reiter, P Fuchs, D Lachinov… - Ophthalmology …, 2023 - Elsevier
Purpose To investigate the progression of geographic atrophy secondary to nonneovascular
age-related macular degeneration in early and later stage lesions using artificial intelligence …

The issue of end point discordance in dry age-related macular degeneration: how might clinical trials demonstrate a functional benefit?

EM Lad, U Chakravarthy - Ophthalmology, 2023 - aaojournal.org
Age-related macular degeneration (AMD) is a disorder of the macula characterized in its
early and intermediate stages by the presence of drusen and pigmentary abnormalities in …

Perspectives from clinical trials: is geographic atrophy one disease?

S Sivaprasad, S Chandra, J Kwon, N Khalid, V Chong - Eye, 2023 - nature.com
Geographic atrophy (GA) is currently an untreatable condition. Emerging evidence from
recent clinical trials show that anti-complement therapy may be a successful treatment …