The intertwined roles of oxidative stress and endoplasmic reticulum stress in glaucoma

DJ Hurley, C Normile, M Irnaten, C O'Brien - Antioxidants, 2022 - mdpi.com
Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …

Traumatic brain injury: an age-dependent view of post-traumatic neuroinflammation and its treatment

C Delage, T Taib, C Mamma, D Lerouet, VC Besson - Pharmaceutics, 2021 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability all over the world. TBI
leads to (1) an inflammatory response,(2) white matter injuries and (3) neurodegenerative …

Traumatic brain injury-related optic nerve damage

J Qiu, M Boucher, G Conley, Y Li… - … of Neuropathology & …, 2022 - academic.oup.com
Vision disorders are associated with traumatic brain injury (TBI) in 20%–40% of clinical
cases and involve a diverse set of potential symptoms that can present acutely or …

Brief Oxygen Exposure after Traumatic Brain Injury Hastens Recovery and Promotes Adaptive Chronic Endoplasmic Reticulum Stress Responses

JN Torrens, SM Hetzer, NK Evanson - International Journal of Molecular …, 2023 - mdpi.com
Traumatic brain injury (TBI) is a major public health concern, particularly in adolescents who
have a higher mortality and incidence of visual pathway injury compared to adult patients …

Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway

Y Zhou, Y Zhang, BOA Botchway, M Huang… - Metabolic Brain Disease, 2024 - Springer
Traumatic brain injury (TBI), as a serious central nervous system disease, can result in
severe neurological dysfunction or even disability and death of patients. The early and …

Chronic histological outcomes of indirect traumatic optic neuropathy in adolescent mice: persistent degeneration and temporally regulated glial responses

SM Hetzer, EM Shalosky, JN Torrens, NK Evanson - Cells, 2021 - mdpi.com
Injury to the optic nerve, termed, traumatic optic neuropathy (TON) is a known comorbidity of
traumatic brain injury (TBI) and is now known to cause chronic and progressive retinal …

Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries

SM Hetzer, C O'Connell, V Lallo, M Robson… - Experimental …, 2024 - Elsevier
Over 3 million people in the United States live with long-term disability because of a
traumatic brain injury (TBI). The purpose of this study was to characterize and compare two …

Deubiquitylase OTUD3 mediates endoplasmic reticulum stress through regulating fortilin stability to restrain dopaminergic neurons apoptosis

L Chen, X Huan, F Jia, Z Zhang, M Bi, L Fu, X Du… - Antioxidants, 2023 - mdpi.com
OTU domain-containing protein 3 (OTUD3) knockout mice exhibited loss of nigral
dopaminergic neurons and Parkinsonian symptoms. However, the underlying mechanisms …

Complement propagates visual system pathology following traumatic brain injury

DM Borucki, B Rohrer, S Tomlinson - Journal of neuroinflammation, 2024 - Springer
Background Traumatic brain injury (TBI) is associated with the development of visual system
disorders. Visual deficits can present with delay and worsen over time, and may be …

Visual Impairment in Pre-Clinical Models of Mild Traumatic Brain Injury

G Orbach, EJ Melendes, K Warren, J Qiu… - Journal of …, 2024 - liebertpub.com
Impairment in visual function is common after traumatic brain injury (TBI) in the clinical
setting, a phenomenon that translates to pre-clinical animal models as well. In Morris et …