Astrocyte endfeet in brain function and pathology: open questions

B Díaz-Castro, S Robel, A Mishra - Annual Review of …, 2023 - annualreviews.org
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

The role of astrocyte‐mediated plasticity in neural circuit development and function

NA Perez-Catalan, CQ Doe, SD Ackerman - Neural development, 2021 - Springer
Neuronal networks are capable of undergoing rapid structural and functional changes called
plasticity, which are essential for shaping circuit function during nervous system …

Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse

Y Zhang, SA Sloan, LE Clarke, C Caneda, CA Plaza… - Neuron, 2016 - cell.com
The functional and molecular similarities and distinctions between human and murine
astrocytes are poorly understood. Here, we report the development of an immunopanning …

Astrocytes and disease: a neurodevelopmental perspective

AV Molofsky, R Krenick, E Ullian, H Tsai… - Genes & …, 2012 - genesdev.cshlp.org
Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity

W Peng, X Liu, G Ma, Z Wu, Z Wang, X Fei, M Qin… - Cell discovery, 2023 - nature.com
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is
generally thought to be involved. Here we show multiple lines of evidence supporting that …

Astrocyte development and heterogeneity

OA Bayraktar, LC Fuentealba… - Cold Spring …, 2015 - cshperspectives.cshlp.org
Astrocytes have many roles within the brain parenchyma, and a subpopulation restricted to
germinal niches functions as neural stem cells (NSCs) that produce various types of …

Astrocyte development: a guide for the perplexed

AV Molofsky, B Deneen - Glia, 2015 - Wiley Online Library
Astrocytes are the predominant cell type in the brain and perform key functions vital to CNS
physiology, including blood brain barrier formation and maintenance, synaptogenesis …

[HTML][HTML] Formation and maintenance of the BBB

M Blanchette, R Daneman - Mechanisms of development, 2015 - Elsevier
The central nervous system (CNS) is vascularized by a dense capillary network that is
critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from …

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

AV Molofsky, KW Kelley, HH Tsai, SA Redmond… - Nature, 2014 - nature.com
Astrocytes, the most abundant cells in the central nervous system, promote synapse
formation and help to refine neural connectivity. Although they are allocated to spatially …

Neurovascular coupling in development and disease: focus on astrocytes

TL Stackhouse, A Mishra - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …