DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …
Epigenome‐wide association studies in asthma: a systematic review
Objective Asthma is a common chronic respiratory airway disease influenced by
environmental factors and possibly their interaction with the human genome causing …
environmental factors and possibly their interaction with the human genome causing …
An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging
Recent studies have demonstrated that the DNA methylome changes with age. This
epigenetic drift may have deep implications for cellular differentiation and disease …
epigenetic drift may have deep implications for cellular differentiation and disease …
Comparative epigenome analysis using Infinium DNA methylation BeadChips
The arrival of the Infinium DNA methylation BeadChips for mice and other nonhuman
mammalian species has outpaced the development of the informatics that supports their use …
mammalian species has outpaced the development of the informatics that supports their use …
Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads
Here we show that striated muscle preferentially expressed protein kinase α (Spegα)
maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of …
maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of …
Body weight and high‐fat diet are associated with epigenetic aging in female members of the BXD murine family
JV Sandoval‐Sierra, AHB Helbing, EG Williams… - Aging cell, 2020 - Wiley Online Library
DNA methylation (DNAm) is shaped by genetic and environmental factors and modulated by
aging. Here, we examine interrelations between epigenetic aging, body weight (BW), and …
aging. Here, we examine interrelations between epigenetic aging, body weight (BW), and …
Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance
Acquired PARP inhibitor (PARPi) resistance in BRCA1-or BRCA2-mutant ovarian cancer
often results from secondary mutations that restore expression of functional protein …
often results from secondary mutations that restore expression of functional protein …
DNA demethylation triggers cell free DNA release in colorectal cancer cells
V Pessei, M Macagno, E Mariella, N Congiusta… - Genome Medicine, 2024 - Springer
Background Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant
promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring of …
promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring of …
Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts
U Perron, E Grassi, A Chatzipli, M Viviani… - Nature …, 2024 - nature.com
Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical
studies. PDXs offer clear advantages over simpler in vitro cancer models-such as cancer cell …
studies. PDXs offer clear advantages over simpler in vitro cancer models-such as cancer cell …