Obesity phenotypes, diabetes, and cardiovascular diseases

ME Piché, A Tchernof, JP Després - Circulation research, 2020 - Am Heart Assoc
This review addresses the interplay between obesity, type 2 diabetes mellitus, and
cardiovascular diseases. It is proposed that obesity, generally defined by an excess of body …

Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management

IJ Neeland, P Poirier, JP Després - Circulation, 2018 - Am Heart Assoc
The prevalence of obesity has increased globally over the last 2 decades. Although the body
mass index has been a convenient and simple index of obesity at the population level …

Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures–2019 update: cosponsored …

JI Mechanick, C Apovian, S Brethauer… - Surgery for Obesity and …, 2020 - Elsevier
Objective The development of these updated clinical practice guidelines (CPG) was
commissioned by the American Association of Clinical Endocrinologists, The Obesity …

Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update

ME Piché, P Poirier, I Lemieux, JP Després - Progress in cardiovascular …, 2018 - Elsevier
Obesity is recognized as a heterogeneous condition in which individuals with similar body
mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to …

Obesity: pathophysiology and management

KM Gadde, CK Martin, HR Berthoud… - Journal of the American …, 2018 - jacc.org
Obesity continues to be among the top health concerns across the globe. Despite our failure
to contain the high prevalence of obesity, we now have a better understanding of its …

[HTML][HTML] Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery

OA Shariq, TJ McKenzie - Gland surgery, 2020 - ncbi.nlm.nih.gov
Obesity is a significant public health challenge worldwide and is inextricably linked to
adverse cardiovascular outcomes. The relationship between excess adiposity and …

On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations

A Qasim, M Turcotte, RJ de Souza… - Obesity …, 2018 - Wiley Online Library
Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Metabolic surgery: weight loss, diabetes, and beyond

M Pareek, PR Schauer, LM Kaplan, LA Leiter… - Journal of the American …, 2018 - jacc.org
The alarming rise in the worldwide prevalence of obesity is paralleled by an increasing
burden of type 2 diabetes mellitus. Metabolic surgery is the most effective means of …

Change in fracture risk and fracture pattern after bariatric surgery: nested case-control study

C Rousseau, S Jean, P Gamache, S Lebel, F Mac-Way… - Bmj, 2016 - bmj.com
Objective To investigate whether bariatric surgery increases the risk of fracture. Design
Retrospective nested case-control study. Setting Patients who underwent bariatric surgery in …

Management of Obesity in Cardiovascular Practice: JACC Focus Seminar

JP Despres, AC Carpentier, A Tchernof… - Journal of the American …, 2021 - jacc.org
Obesity contributes to reduced life expectancy because of its link with type 2 diabetes and
cardiovascular disease. Yet, targeting this poorly diagnosed, ill-defined, and …