Recent advances in the identification of biosynthetic genes and gene clusters of the polyketide-derived pathways for anthraquinone biosynthesis and biotechnological …

NK Mund, E Čellárová - Biotechnology Advances, 2023 - Elsevier
Natural anthraquinones are represented by a large group of compounds. Some of them are
widespread across the kingdoms, especially in bacteria, fungi and plants, while the others …

The 'emodin family'of fungal natural products–amalgamating a century of research with recent genomics-based advances

KMJ de Mattos-Shipley, TJ Simpson - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to 2022 A very large group of biosynthetically linked fungal secondary
metabolites are formed via the key intermediate emodin and its corresponding anthrone …

Discovery of the Biosynthetic Pathway of Beticolin 1 Reveals a Novel Non‐Heme Iron‐Dependent Oxygenase for Anthraquinone Ring Cleavage

X Hou, H Xu, Z Deng, Y Yan, Z Yuan… - Angewandte Chemie …, 2022 - Wiley Online Library
This study used light‐mediated comparative transcriptomics to identify the biosynthetic gene
cluster of beticolin 1 in Cercospora. It contains an anthraquinone moiety and an unusual …

Berberine bridge enzyme-like oxidase-catalysed double bond isomerization acts as the pathway switch in cytochalasin synthesis

JM Zhang, X Liu, Q Wei, C Ma, D Li, Y Zou - Nature Communications, 2022 - nature.com
Cytochalasans (CYTs), as well as their polycyclic (pcCYTs) and polymerized (meCYTs)
derivatives, constitute one of the largest families of fungal polyketide-nonribosomal peptide …

Branching and converging pathways in fungal natural product biosynthesis

X Wei, WG Wang, Y Matsuda - Fungal Biology and Biotechnology, 2022 - Springer
In nature, organic molecules with great structural diversity and complexity are synthesized
by utilizing a relatively small number of starting materials. A synthetic strategy adopted by …

Elucidation of the Complete Biosynthetic Pathway of Phomoxanthone A and Identification of a Para–Para Selective Phenol Coupling Dimerase

SW Yuan, SH Chen, H Guo, LT Chen, HJ Shen… - Organic …, 2022 - ACS Publications
Fungal cytochrome P450 enzymes have been shown to catalyze regio-and stereoselective
oxidative intermolecular phenol coupling. However, an enzyme capable of catalyzing …

Discovery of a Fungal P450 with an Unusual Two-Step Mechanism for Constructing a Bicyclo [3.2. 2] nonane Skeleton

H Xu, Z Yuan, S Yang, Z Su, XD Hou… - Journal of the …, 2024 - ACS Publications
The successful biomimetic or chemoenzymatic synthesis of target natural products (NPs)
and their derivatives relies on enzyme discovery. Herein, we discover a fungal P450 BTG5 …

Biosynthesis of Polycyclic Natural Products from Conjugated Polyenes via Tandem Isomerization and Pericyclic Reactions

K Niwa, M Ohashi, K Xie, CY Chiang… - Journal of the …, 2023 - ACS Publications
We report biosynthetic pathways that can synthesize and transform conjugated octaenes
and nonaenes to complex natural products. The biosynthesis of (−)-PF1018 involves an …

Biosynthetic pathways of dimeric natural products containing bisanthraquinone and related xanthones

Z Yuan, H Xu, Y Zhang, Y Rao - ChemBioChem, 2023 - Wiley Online Library
Many dimeric natural products containing bisanthraquinone and related xanthones with
diverse structures and versatile bioactivities have been isolated over the years. However …

Three-dimensional structural alignment based discovery and molecular basis of AtoB, catalyzing linear tetracyclic formation

K Ma, J Liu, Z Huang, M Wu, D Liu, J Ren, A Fan… - Chemical …, 2024 - pubs.rsc.org
Enzymes from the nuclear transport factor 2-like (NTF2-like) superfamily represent a rare
group of biocatalysts with diverse catalytic functions facilitating intriguing skeleton …