Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …

Primary tumors are known to constantly shed a large number of cancer cells into systemic
dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases …

Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited
response to treatment. Tractable methods to identify and interrogate pathways involved in …

Markers are needed to facilitate early detection of pancreatic ductal adenocarcinoma
(PDAC), which is often diagnosed too late for effective therapy. Starting with a PDAC cell …

The application of primary organoid cultures containing epithelial and mesenchymal
elements to cancer modeling holds promise for combining the accurate multilineage …

The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …

Tractable and accurate disease models are essential for understanding disease
pathogenesis and for developing new therapeutics. As stem cells are capable of self …

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new
treatment and diagnostic approaches are urgently needed. For such breakthroughs to be …

Pioneer transcription factors such as OCT4 can target silent genes embedded in
nucleosome-dense regions. How nucleosome interaction enables transcription factors to …