The prevalence of immune-mediated disorders, including autoimmune conditions and
allergies, is steadily increasing. However, current therapeutic approaches are often non …

Autoimmune disorders have risen to be among the most prevalent chronic diseases across
the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily …

Abstract Interleukin-2 (IL-2) therapies targeting the high affinity IL-2 receptor expressed on
regulatory T cells (Tregs) have shown promising therapeutic benefit in autoimmune …

Regulatory T cells (Treg) play key roles in inhibiting effective antitumor immunity. However,
therapeutic Treg depletion fails to consistently enhance immune responses due to the …

Abstract The interleukin-2 (IL-2) cytokine plays a crucial role in regulating immune
responses and maintaining immune homeostasis. Its immunosuppressive effects have been …

Multiple Sclerosis (MS) is an autoimmune condition targeting the central nervous system
(CNS) characterized by focal demyelination with inflammation, causing neurodegeneration …

Autoimmune diseases, allergies, transplant rejections, generation of antidrug antibodies,
and chronic inflammatory diseases have impacted a large group of people across the globe …

Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …

Highlights•Autoimmune diseases impact more women than men and are underrepresented
in research.•Imbalance of T-cell populations is inherent to most autoimmune …

Multiple sclerosis is an autoinflammatory condition that results in damage to myelinated
neurons in affected patients. While disease-modifying treatments have been successful in …