Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …

DNA nanotechnology has seen large developments over the last 30 years through the
combination of solid phase synthesis and the discovery of DNA nanostructures. Solid phase …

Small ions of high charge density (kosmotropes) bind water molecules strongly, whereas
large monovalent ions of low charge density (chaotropes) bind water molecules weakly …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Transition metal complexes that reversibly bind to DNA have been studied for almost 30
years. In the last few years a variety of new systems have been developed, employing a …

This tutorial review summarizes chemical, biophysical and cellular biological properties of
formally substitution-inert “non-covalent” polynuclear platinum complexes (PPCs). We …

The cyanine dyes are among the oldest classes of synthetic compounds but continue to find
applications in a variety of fields. In many cases, the dyes act as fluorescent labels for …

The dynamics of biological processes depend on the structure and flexibility of the
interacting molecules. In particular, the conformational diversity of DNA allows for large …

Significant progress has been made over the past few years in studies of drug—DNA
interactions. Structure-based design strategies have yielded new DNA-binding agents with …