Healthy functioning of the female reproductive tract (FRT) depends on balanced and
dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The …

The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic
tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily …

Endometrial cancer (EC) is the most common gynecologic malignancy in the western world
with more than 280,000 cases per year worldwide. Prognosis for EC at early stages, when …

Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in
complete tumor remission and are frequently challenged by the appearance of refractory cell …

Glutamine commonly becomes a conditionally essential amino acid in cancer. Glutamine is
supplied to the cell by transporters such as ASCT2 (SLC1A5), which is frequently …

CTCF is a haploinsufficient tumour suppressor gene with diverse normal functions in
genome structure and gene regulation. However the mechanism by which CTCF …

Previous study claimed that disc degeneration may be preceded by structure and matrix
changes in the intervertebral disc (IVD) which coincide with the loss of distinct notochordally …

The proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs) needed
to be promoted for their use in stem cell-based therapy for large bone defects. This study …

2D cell culture models are simple, low cost, well suited for automated high-throughput drug
screening, and have been successfully used to discover many clinically relevant anti-cancer …

Abstract Objectives The PI3K/AKT/mTOR pathway is frequently overactivated in endometrial
cancer (EC). We assessed the efficacy of ABTL0812, a novel first-in-class molecule …