The excision of introns from pre-mRNA is a crucial process in the expression of the majority
of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein …

Arginine modification can be a “switch” to regulate DNA transcription and a post-
translational modification via methylation of a variety of cellular targets involved in signal …

Mantle cell lymphoma (MCL) is an incurable B-cell malignancy that comprises up to 6% of
non-Hodgkin lymphomas diagnosed annually and is associated with a poor prognosis. The …

Hemophagocytic lymphohistiocytosis (HLH) is a rare but aggressive and potentially lethal
hyperinflammatory syndrome characterized by pathologic immune activation and excessive …

Mantle cell lymphoma (MCL) is an incurable and aggressive subtype of non-Hodgkin B-cell
lymphoma. Increased lipid uptake, storage, and lipogenesis occur in a variety of cancers …

Despite recent therapeutic advancements in the general field of non-Hodgkin lymphoma,
effective treatment of relapsed or refractory (R/R) mantle cell lymphoma (MCL) remains a …

Abstract Phosphoinositide 3-kinase (PI3K) pathway, controlling diverse functions in cells, is
one of the most frequently dysregulated pathways in cancer. Several negative regulators …

Background Methylthioadenosine phosphorylase (MTAP) and protein arginine
methyltransferase 5 (PRMT5) are considered to be a synthetic lethal pair of targets, due to …

The field of transcriptional regulation has revealed the vital role of chromatin modifiers in
human diseases from the beginning of functional exploration to the process of participating …

Objective SUMO-specific protease 3 (SENP3), a member of the SUMO-specific protease
family, reverses the SUMOylation of SUMO-2/3 conjugates. Dysregulation of SENP3 has …