Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Inclusion body myositis (IBM) is often viewed as an enigmatic disease with uncertain
pathogenic mechanisms and confusion around diagnosis, classification and prospects for …

Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

We investigated the relationship between oxidative stress and inflammatory myopathies. We
searched in the current literature the role of mitochondria and respiratory chain defects as …

Background: Targeting of drugs to the subcellular compartments represents one of the
modern trends in molecular pharmacology. The approach for targeting mitochondria was …

Autoimmune diseases develop as a result of chronic inflammation owing to interactions
between genes and the environment. However, the mechanisms by which autoimmune …

Skeletal muscles undergo structural and functional decline with ageing, culminating in
sarcopenia. The underlying neuromuscular mechanisms have been the subject of intense …

Inclusion body myositis (IBM) is a progressive muscle disease affecting patients over the
age of 40, with distinctive clinical and histopathological features. The typical clinical …

Sporadic inclusion body myositis (sIBM) is the most frequently acquired myopathy in patients
over 50 years of age. It is imperative that neurologists and rheumatologists recognize this …