Antibody‐incorporated nanomedicines for cancer therapy

SY Wu, FG Wu, X Chen - Advanced Materials, 2022 - Wiley Online Library
Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

C Rinoldi, SS Zargarian, P Nakielski, X Li… - Small …, 2021 - Wiley Online Library
In recent years, the main quest of science has been the pioneering of the groundbreaking
biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids …

Targeting nucleic acid-based therapeutics to tumors: Challenges and strategies for polyplexes

VC Vetter, E Wagner - Journal of Controlled Release, 2022 - Elsevier
The current medical reality of cancer gene therapy is reflected by more than ten approved
products on the global market, including oncolytic and other viral vectors and CAR T-cells as …

Multifunctional rolling circle transcription-based nanomaterials for advanced drug delivery

X Ma, Y Zhang, K Huang, L Zhu, W Xu - Biomaterials, 2023 - Elsevier
As the up-and-comer in the development of RNA nanotechnology, RNA nanomaterials
based on functionalized rolling circle transcription (RCT) have become promising carriers for …

Novel perspectives towards RNA-based nano-theranostic approaches for cancer management

R Arshad, I Fatima, S Sargazi, A Rahdar… - Nanomaterials, 2021 - mdpi.com
In the fight against cancer, early diagnosis is critical for effective treatment. Traditional
cancer diagnostic technologies, on the other hand, have limitations that make early …

Toward Precise Antitumoral Photodynamic Therapy Using a Dual Receptor‐Mediated Bioorthogonal Activation Approach

JCH Chu, CTT Wong, DKP Ng - … Chemie International Edition, 2023 - Wiley Online Library
Targeted delivery and specific activation of photosensitizers can greatly improve the
treatment outcome of photodynamic therapy. To this end, we report herein a novel dual …

Nanoengineered Polymeric RNA Nanoparticles for Controlled Biodistribution and Efficient Targeted Cancer Therapy

T Kim, HS Han, K Yang, YM Kim, K Nam, KH Park… - ACS …, 2024 - ACS Publications
RNA nanotechnology, including rolling circle transcription (RCT), has gained increasing
interest as a fascinating siRNA delivery nanoplatform for biostable and tumor-targetable …

[HTML][HTML] Clinical progress of nanomedicine-based RNA therapies

SA Lim, A Cox, M Tung, EJ Chung - Bioactive Materials, 2022 - Elsevier
The clinical application of nanoparticles (NPs) to deliver RNA for therapy has progressed
rapidly since the FDA approval of Onpattro® in 2018 for the treatment of polyneuropathy …

Recent advancements in the design of nanodelivery systems of siRNA for cancer therapy

DN Yadav, MS Ali, AM Thanekar, SV Pogu… - Molecular …, 2022 - ACS Publications
RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for
cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that …

Nucleic acid-based artificial nanocarriers for gene therapy

L Zhu, J Luo, K Ren - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Nucleic acid nanotechnology is a powerful tool in the fields of biosensing and nanomedicine
owing to their high editability and easy synthesis and modification. Artificial nucleic acid …