Comparing HIV‐1 and HIV‐2 infection: Lessons for viral immunopathogenesis

S Nyamweya, A Hegedus, A Jaye… - Reviews in medical …, 2013 - Wiley Online Library
SUMMARY HIV‐1 and HIV‐2 share many similarities including their basic gene
arrangement, modes of transmission, intracellular replication pathways and clinical …

Update on human immunodeficiency virus (HIV)-2 infection

OT Campbell-Yesufu, RT Gandhi - Clinical infectious diseases, 2011 - academic.oup.com
Infection with human immunodeficiency virus type 2 (HIV-2) occurs mainly in West Africa, but
an increasing number of cases have been recognized in Europe, India, and the United …

Hiv-2 molecular epidemiology

B Visseaux, F Damond, S Matheron… - Infection, Genetics and …, 2016 - Elsevier
Abstract The Simian Immunodeficiency Virus of sooty mangabeys (SIVsmm) has been
revealed to be at the origin of Human Immunodeficiency Virus type 2 (HIV-2) in humans …

90-90-90 for HIV-2? Ending the HIV-2 epidemic by enhancing care and clinical management of patients infected with HIV-2

GS Gottlieb, DN Raugi, RA Smith - The lancet HIV, 2018 - thelancet.com
Distinct from HIV-1 and often neglected in the global campaign to end the AIDS epidemic,
HIV-2 presents unique and underappreciated challenges in diagnosis, clinical care …

Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study

J Esbjörnsson, F Månsson, A Kvist, ZJ da Silva… - The lancet HIV, 2019 - thelancet.com
Summary Background HIV type 2 (HIV-2) is considered more benign and has fewer
pathogenic consequences than HIV type 1 (HIV-1) for most infected individuals. However …

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection

MP Cabral-Piccin, L Papagno, X Lahaye… - …, 2023 - thelancet.com
Background CD8+ T cells equipped with a full arsenal of antiviral effector functions are
critical for effective immune control of HIV-1. It has nonetheless remained unclear how best …

HIV-2 as a model to identify a functional HIV cure

J Esbjörnsson, M Jansson, S Jespersen… - AIDS research and …, 2019 - Springer
Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined
mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years …

Mortality and survival patterns of people living with HIV-2

B Tchounga, DK Ekouevi, E Balestre… - Current Opinion in HIV …, 2016 - journals.lww.com
People living with HIV-2 initiate ART later than HIV-1 and HIV duals, resulting in higher
disease progression and mortality rate. The clinical management of HIV-2 infected patients …

HIV-2 inhibits HIV-1 gene expression via two independent mechanisms during cellular co-infection

V Yapo, K Majumder, PR Tedbury, X Wen… - Journal of …, 2023 - Am Soc Microbiol
Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency
syndrome (AIDS). The two main forms of HIV are HIV-1 and HIV-2; in the clinic, each is …

Immune responses to retroviruses

A Saez-Cirion, N Manel - Annual review of immunology, 2018 - annualreviews.org
Retroviruses are genome invaders that have shared a long history of coevolution with
vertebrates and their immune system. Found endogenously in genomes as traces of past …