Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

Stim1 and Orai1 are ubiquitous proteins that have long been known to mediate Ca2+
release-activated Ca2+ (CRAC) current (ICRAC) and store-operated Ca2+ entry (SOCE) …

Cardiac hypertrophy, initiated by a variety of physiological or pathological stimuli
(hemodynamic or hormonal stimulation or infarction), is a critical early adaptive …

In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …

Background Right ventricular (RV) function is the most important prognostic factor for
pulmonary arterial hypertension (PAH) patients. The progressive increase of pulmonary …

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in
response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic …

Background—Stromal interaction molecule 1 (STIM1) is a dynamic calcium signal
transducer implicated in hypertrophic growth of cardiomyocytes. STIM1 is thought to act as …

Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-
operated Ca2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key …

Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse
cellular functions including cell survival, metabolism, and transcription. As a result …

Ca2+ ion channels are critical in a variety of physiological events, including cell growth,
differentiation, gene transcription and apoptosis. One such essential entry pathway for …