Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

The vertebrate intestine experiences a range of intrinsically generated and external forces
during both development and adult homeostasis. It is increasingly understood how the …

Background & Aims Fibrosis and tissue stiffening are hallmarks of inflammatory bowel
disease (IBD). We have hypothesized that the increased stiffness directly contributes to the …

All cells in the body are exposed to physical force in the form of tension, compression,
gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular …

Intestinal organoids, derived from intestinal stem cell self-organization, recapitulate the
tissue structures and behaviors of the intestinal epithelium, which hold great potential for the …

Human intestinal organoids (HIOs) derived from pluripotent stem cells or adult stem cell
biopsies represent a powerful platform to study human development, drug testing, and …

The colon serves as a primary target for pharmaceutical compound screening and disease
modelling. To better study colon diseases and develop treatments, engineered in vitro …

Mechanosensation is essential for normal gastrointestinal (GI) function, and abnormalities in
mechanosensation are associated with GI disorders. There are several mechanosensitive …

The complex and dynamic environment of the gastrointestinal tract shapes one of the fastest
renewing tissues in the human body, the intestinal epithelium. Considering the lack of …

On a curved surface, epithelial cells can adapt to geometric constraints by tilting and by
exchanging their neighbors from apical to basal sides, known as an apico-basal topological …