Mammalian epidermis produces and delivers large quantities of glucosylceramide and
sphingomyelin precursors to stratum corneum extracellular domains, where they are …

dihydroxyvitamin D3 [1, 25 (OH) 2D3] is a well‐known potent regulator of cell growth and
differentiation and there is recent evidence of an effect on cell death, tumour invasion and …

Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal
barrier disruption and intense systemic inflammation. Previously, we showed that exosomes …

Embracing both the art and science of skin care, Cosmetic Dermatology covers a wide range
of interventions and treatments designed to maintain and beautify healthy skin and protect …

It has been documented previously that defects in the generation of C18-ceramide, a
product of ceramide synthase 1 (CerS1), also known as longevity assurance gene 1 …

Sphingolipids, a group of lipids containing the sphingoid base, have both structural and
biological functions in human epidermis. Ceramides, as a part of extracellular lipids in the …

Ceramides are the major component of the stratum corneum, accounting for 30%-40% of
stratum corneum lipids by weight, and are composed of at least seven molecular groups …

The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-
phosphate (S1P) have important roles in several types of signaling and regulation of many …

The skin consists of the epidermis, dermis and subcutis. The epidermis is primarily
comprised of keratinocytes and is separated into four layers according to the stage of …

Ceramide is an integral part of the extracellular lipid bilayer of the stratum corneum (SC) that
forms the permeability barrier of the skin. The production of SC ceramides is catalyzed by …