Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …

MRI and 1H magnetic resonance spectroscopy (1HMRS) are the main neuroimaging
methods to study mitochondrial diseases. MRI can demonstrate seven 'elementary'central …

Objective To investigate whether early neurochemical abnormalities are detectable by high‐
field magnetic resonance spectroscopy (MRS) in individuals with spinocerebellar ataxias …

Robust biomarkers of neurodegeneration are critical for testing of neuroprotective therapies.
The clinical applicability of such biomarkers requires sufficient sensitivity to detect disease in …

Abstract Knowledge of physiological aging in healthy human brain is increasingly important
for neuroscientific research and clinical diagnosis. To investigate neuronal decline in normal …

Spinocerebellar ataxias (SCAs) belong to polyglutamine repeat disorders and are
characterized by a predominant atrophy of the cerebellum and the pons. Proton magnetic …

Hereditary and sporadic neurodegenerative ataxias are movement disorders that affect the
cerebellum. Robust and objective biomarkers are critical for treatment trials of ataxias. In …

Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have
been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD) …

Proton magnetic resonance (MR) spectroscopy of the brain is a non-invasive, in vivo
technique that allows investigation into regional chemical environments. Its complementary …

Gluten ataxia is a rare immune-mediated neurological disorder caused by the ingestion of
gluten. The diagnosis is not straightforward as antibodies are present in only up to 38% of …