T helper-17 (Th17) cells, which mainly produce IL-17, are associated with development of
various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases …

The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive
sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin …

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

The AHR is an environmental sensor and transcription factor activated by a variety of man-
made and natural ligands, which has recently emerged as a critical regulator of homeostasis …

Cytochrome P450 (CYP) 1A enzymes are considerably expressed in the human intestine
and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this …

Recently, the mTOR signaling has emerged as an important player in the pathogenesis of
psoriasis. We previously found that 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced …

Abstract Ambient particulate matter 2.5 (PM 2.5) is one of the main components of air
pollutants, which can absorb many polycyclic aromatic hydrocarbons and metals. The effect …

Bisphenols (BPs) are environmental pollutants with relevant DNA damage in human
population; however, they are generally inactive in standard mutagenicity assays, possibly …

Although numerous studies imply a correlation between chemical contamination and an
impaired immunocompetence of wildlife populations, the assessment of immunomodulatory …

Pulmonary fibrosis (PF) results from excessive extracellular matrix (ECM) deposition and
tissue remodeling after activation of fibroblasts into myofibroblasts. Abnormally deposited …