Prevention of epileptogenesis after brain trauma is an unmet medical challenge. Recent
molecular profiling studies have provided an insight into molecular changes that contribute …

Work in recent years has revealed an abundance of possible new treatment targets for
fragile X syndrome (FXS). The use of animal models, including the fragile X knockout mouse …

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability.
Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial …

Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X
mental retardation protein), a repressor of mRNA translation. According to the metabotropic …

Background No animal models of autism spectrum disorders (ASD) with good construct
validity are currently available; using genetic models of pathologies characterized by ASD …

Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability,
resulting from a mutation in the FMR1 gene and subsequent loss of its protein product …

Fragile X syndrome (FXS) is an inherited neurodevelopmental disease caused by loss of
function of the fragile X mental retardation protein (FMRP). In the absence of FMRP …

Axonal branching and terminal arborization are fundamental events during the
establishment of synaptic connectivity. They are triggered by assembly of actin filaments …

Fragile X syndrome is the leading heritable form of cognitive impairment and the leading
known monogenic disorder associated with autism. Roughly one-quarter of children with this …

Development of the nervous system requires efficient extension and guidance of axons and
dendrites culminating in synapse formation. Axonal growth and navigation during …