Although mood disorders constitute leading causes of disability, until recently little was
known about their pathogenesis. The delineation of anatomical networks that support …

This review begins with a brief historical overview of attempts in the first half of the 20th
century to discern brain systems that underlie emotion and emotional behavior. These early …

The ability to regulate emotions is an important part of adaptive functioning in society.
Advances in cognitive and affective neuroscience and biological psychiatry have facilitated …

Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …

The anterior cingulate cortex (ACC) ventral to the genu of the corpus callosum has been
implicated in the modulation of emotional behavior on the basis of neuroimaging studies in …

BACKGROUND: Recent genetic results have indicated that the two major, classically distinct
forms of psychosis–schizophrenia and bipolar disorder–may share causative factors in …

From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is
almost certainly the case that many somewhat similar, but subtly different, pathological …

Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia,
bipolar disorder, and major depression) represent two major suites of disorders of human …

Both major depressive disorder and bipolar disorder are the subject of a voluminous
imaging and genetics literature. Here, we attempt a comprehensive review of MRI and …

The antisaccade task is a measure of volitional control of behavior sensitive to fronto‐striatal
dysfunction. Here we outline important issues concerning antisaccade methodology …