K Turnheim - Experimental gerontology, 2003 - Elsevier
The age-related changes in the functions and composition of the human body require adjustments of drug selection and dosage for old individuals. Drug excretion via the kidneys …
W Doehner, D Ural, KG Haeusler… - European journal of …, 2018 - Wiley Online Library
Heart failure (HF) is a complex clinical syndrome with multiple interactions between the failing myocardium and cerebral (dys‐) functions. Bi‐directional feedback interactions …
KM Sink, X Leng, J Williamson… - Archives of internal …, 2009 - jamanetwork.com
Background Hypertension (HTN) is a risk factor for dementia, and animal studies suggest that centrally active angiotensin-converting enzyme (ACE) inhibitors (those that cross the …
J Gunstad, G Strain, MJ Devlin, R Wing… - Surgery for obesity and …, 2011 - Elsevier
BACKGROUND:: Growing evidence has shown that obesity is associated with poor neurocognitive outcomes. Bariatric surgery has been shown to be an effective intervention …
K Turnheim - Experimental gerontology, 2004 - Elsevier
Drug dosage in the elderly requires an understanding of the age-dependent changes in drug disposition and sensitivity. The most important pharmacokinetic alteration is a decline …
Obesity is a significant contemporary health concern that carries wide-ranging implications for society, as well as for individual health and well-being. In particular, the …
Although the fear response is an adaptive response to threatening situations, a number of psychiatric disorders feature prominent fear-related symptoms caused, in part, by failures of …
N Coley, S Andrieu, V Gardette… - Epidemiologic …, 2008 - academic.oup.com
The prevention of neurodegenerative dementias, such as Alzheimer disease, is a growing public health concern, because of a lack of effective curative treatment options and a rising …
GE Smith - American Psychologist, 2016 - psycnet.apa.org
Behavioral prevention strategies can help maintain high levels of cognition and functional integrity, and can reduce the social, medical, and economic burden associated with …