Cell therapy for neurological disorders

SP Svendsen, CN Svendsen - Nature Medicine, 2024 - nature.com
Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …

Neural stem cells for early ischemic stroke

MH Hamblin, JP Lee - International journal of molecular sciences, 2021 - mdpi.com
Clinical treatments for ischemic stroke are limited. Neural stem cell (NSC) transplantation
can be a promising therapy. Clinically, ischemia and subsequent reperfusion lead to …

In-vivo programmable acoustic manipulation of genetically engineered bacteria

Y Yang, Y Yang, D Liu, Y Wang, M Lu, Q Zhang… - Nature …, 2023 - nature.com
Acoustic tweezers can control target movement through the momentum interaction between
an acoustic wave and an object. This technology has advantages over optical tweezers for …

Vitality‐Enhanced Dual‐Modal Tracking System Reveals the Dynamic Fate of Mesenchymal Stem Cells for Stroke Therapy

J Xu, Y Zhang, Y Liu, Y You, F Li, Y Chen, L Xie… - Small, 2022 - Wiley Online Library
Mesenchymal stem cell (MSC) therapy via intravenous transplantation exhibits great
potential for brain tissue regeneration, but still faces thorny clinical translation challenges as …

Decidual CXCR4+CD56brightNK cells as a novel NK subset in maternal–foetal immune tolerance to alleviate early pregnancy failure

Y Tao, YH Li, D Zhang, L Xu, JJ Chen… - Clinical and …, 2021 - Wiley Online Library
Natural killer (NK) cells preferentially accumulate at maternal–foetal interface and are
believed to play vital immune‐modulatory roles during early pregnancy and related …

Understanding Neural Stem Cell Regulation in Vivo and Applying the Insights to Cell Therapy for Strokes

N Genet, KK Hirschi - Regenerative Medicine, 2021 - Taylor & Francis
The use of neural stem cell (NSC) therapy for the treatment of stroke patients is successfully
paving its way into advanced phases of large-scale clinical trials. To understand how to …

Strategies and progress in CXCR4-targeted anti-human immunodeficiency virus (HIV) therapeutic development

LSM Huang, EY Snyder… - Clinical Infectious …, 2021 - academic.oup.com
The acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has been a global public health challenge for several decades. The majority of …

Therapeutic potential of chinese medicine for endogenous neurogenesis: A promising candidate for stroke treatment

L Li, X Li, R Han, M Wu, Y Ma, Y Chen, H Zhang, Y Li - Pharmaceuticals, 2023 - mdpi.com
Strokes are a leading cause of morbidity and mortality in adults worldwide. Extensive
preclinical studies have shown that neural-stem-cell-based treatments have great …

Maternal sevoflurane exposure increases the epilepsy susceptibility of adolescent offspring by interrupting interneuron development

X Liang, M Jiang, H Xu, T Tang, X Shi, Y Dong, L Xiao… - BMC medicine, 2023 - Springer
Background Exposure to general anesthesia influences neuronal functions during brain
development. Recently, interneurons were found to be involved in developmental …

Modulation of gene expression on a transcriptome-wide level following human neural stem cell transplantation in aged mouse stroke brains

MH Hamblin, R Murad, J Yin, G Vallim, JP Lee - Experimental neurology, 2022 - Elsevier
Introduction Neural stem cell (NSC) transplantation offers great potential for treating
ischemic stroke. Clinically, ischemia followed by reperfusion results in robust …