[HTML][HTML] Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons

B Signal, AJ Phipps, KA Giles, SN Huskins, TR Mercer… - Cells, 2024 - mdpi.com
Neurons are central to lifelong learning and memory, but ageing disrupts their morphology
and function, leading to cognitive decline. Although epigenetic mechanisms are known to …

Evolutionary dynamics of chromatin structure and duplicate gene expression in diploid and allopolyploid cotton

G Hu, CE Grover, DL Vera, PY Lung… - Molecular Biology …, 2024 - academic.oup.com
Polyploidy is a prominent mechanism of plant speciation and adaptation, yet the mechanistic
understandings of duplicated gene regulation remain elusive. Chromatin structure dynamics …

BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer

KA Giles, CM Gould, J Achinger-Kawecka, SG Page… - Clinical …, 2021 - Springer
Background BRG1 (encoded by SMARCA4) is a catalytic component of the SWI/SNF
chromatin remodelling complex, with key roles in modulating DNA accessibility …

BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells

KA Giles, CM Gould, J Achinger-Kawecka, SG Page… - bioRxiv, 2020 - biorxiv.org
Background BRG1 (encoded by SMARCA4) is a catalytic component of the SWI/SNF
chromatin remodelling complex, with key roles in modulating DNA accessibility …

H3K4me3 enrichment defines neuronal age, while a youthful H3K27ac signature is recapitulated in aged neurons

KA Giles, AJ Phipps, JM Cashion, SN Huskins… - bioRxiv, 2021 - biorxiv.org
Neurons live for the lifespan of the individual and underlie our ability for lifelong learning
and memory. However, aging alters neuron morphology and function resulting in age …

BRG1 ATP-dependent chromatin remodelling in prostate cancer: Epigenetic consequences

K Giles - 2018 - unsworks.unsw.edu.au
ABSTRACT ATP-dependent chromatin remodelling complexes are responsible for
establishing and maintaining the positioning of nucleosomes within chromatin, and they …