Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Laboratory testing is important in the diagnosis and monitoring of liver injury and disease.
Current liver tests include plasma markers of injury (eg aminotransferases, γ-glutamyl …

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the
United States. Toxicity begins with a reactive metabolite that binds to proteins. In rodents …

Acute liver failure is a rare and severe consequence of abrupt hepatocyte injury, and can
evolve over days or weeks to a lethal outcome. A variety of insults to liver cells result in a …

Acute liver failure is a rare disorder with high mortality and resource cost. In the developing
world, viral causes predominate, with hepatitis E infection recognised as a common cause in …

Acute liver failure (ALF) due to drug‐induced liver injury (DILI), though uncommon, is a
concern for both clinicians and patients. The Acute Liver Failure Study Group has …

Abbreviated pathogenesis and clinical course of the acute liver failure syndrome. The
pathogenesis and clinical course of the syndrome of acute liver failure (ALF) differs …