Mesenchymal stem cells for the treatment of neurodegenerative disease

N Joyce, G Annett, L Wirthlin, S Olson… - Regenerative …, 2010 - Taylor & Francis
Mesenchymal stem cells/marrow stromal cells (MSCs) present a promising tool for cell
therapy, and are currently being tested in US FDA-approved clinical trials for myocardial …

Critical issues in tissue engineering: biomaterials, cell sources, angiogenesis, and drug delivery systems

H Naderi, MM Matin… - Journal of biomaterials …, 2011 - journals.sagepub.com
Tissue engineering is a newly emerging biomedical technology, which aids and increases
the repair and regeneration of deficient and injured tissues. It employs the principles from …

Therapeutic utility of mesenchymal stromal cell (MSC)-based approaches in chronic neurodegeneration: a glimpse into underlying mechanisms, current status, and …

M Rahbaran, AO Zekiy, M Bahramali… - Cellular & Molecular …, 2022 - Springer
Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated
therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a …

Mesenchymal stem cells: potential in treatment of neurodegenerative diseases

T Tanna, V Sachan - Current stem cell research & therapy, 2014 - ingentaconnect.com
Mesenchymal Stem Cells or Marrow Stromal Cells (MSCs) have long been viewed as a
potent tool for regenerative cell therapy. MSCs are easily accessible from both healthy donor …

Adult cell therapy for brain neuronal damages and the role of tissue engineering

GJR Delcroix, PC Schiller, JP Benoit… - Biomaterials, 2010 - Elsevier
No long term effective treatments are currently available for brain neurological disorders
such as stroke/cerebral ischemia, traumatic brain injury and neurodegenerative disorders …

Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models

YT Lin, Y Chern, CKJ Shen, HL Wen, YC Chang, H Li… - PloS one, 2011 - journals.plos.org
We investigated the therapeutic potential of human bone marrow-derived mesenchymal
stem cells (hBM-MSCs) in Huntington's disease (HD) mouse models. Ten weeks after …

Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease

SD Olson, K Pollock, A Kambal, W Cary… - Molecular …, 2012 - Springer
There is much interest in the use of mesenchymal stem cells/marrow stromal cells (MSC) to
treat neurodegenerative disorders, in particular those that are fatal and difficult to treat, such …

Mesenchymal stem cells as therapeutic agents and potential targeted gene delivery vehicle for brain diseases

B Huang, Y Tabata, JQ Gao - Journal of controlled release, 2012 - Elsevier
Transplantation of mesenchymal stem cells (MSCs) into the injured brain may provide
therapeutic benefits. Several models of brain diseases have been examined, including that …

[HTML][HTML] Neuroprotective effects and magnetic resonance imaging of mesenchymal stem cells labeled with SPION in a rat model of Huntington's disease

L Moraes, A Vasconcelos-dos-Santos, FC Santana… - Stem cell …, 2012 - Elsevier
Bone marrow mesenchymal stem cells (MSC) have been tested and proven effective in
some neurodegenerative diseases, but their tracking after transplantation may be …

Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington's disease following transplantation of bone-marrow-derived …

J Rossignol, KD Fink, AT Crane, KK Davis… - Stem Cell Research & …, 2015 - Springer
Introduction Huntington's disease (HD) is an autosomal dominant disorder caused by an
expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss …