Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …

Wound repair, as one of the most intricate biological mechanisms, is essential to ensure the
formation and integrity of the skin barrier. However, multiple factors can cause delays and …

Currently, the fabrication of a functional vascular network to maintain the viability of
engineered tissues is a major bottleneck in the way of developing a more advanced …

The main pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH)
includes decreased osteogenic capacity of bone marrow-derived mesenchymal stem cells …

Although bone is an organ that displays potential for self-healing after damage, bone
regeneration does not occur properly in some cases, and it is still a challenge to treat large …

Avascular necrosis (AVN) of the femoral head commonly leads to symptomatic osteoarthritis
of the hip. In older patients, hip replacement is a viable option that restores the hip …

Treatment of tendon-to-bone interface injury has long been challenging in sports medicine.
The major obstacle lies with the complicated three-layer structure of the tissue that consists …

Mobilizing endogenous progenitor cells to repair damaged tissue in situ has the potential to
revolutionize the field of regenerative medicine, while the early establishment of a vascular …

Dental pulp stem cells (DPSCs) represent a population of stem cells which could be useful
in oral and maxillofacial reconstruction. They are part of the periendothelial niche, where …

Segmental bone defects that are caused by trauma, infection, tumor resection, or
osteoporotic fractures present significant surgical treatment challenges. Host bone autograft …