Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential
risk factors enables clinicians to identify patients who are more likely to develop bipolar …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …

Depression is caused by a change in neural activity resulting from an increase in glutamate
that drives excitatory neurons and may be responsible for the decline in the activity and …

Importance Observational studies have reported associations between antihypertensive
medication and psychiatric disorders, although the reported direction of association appears …

Hypertension, cardiovascular diseases, and cerebrovascular diseases are associated with
an increased risk of depression, but it remains unclear whether treatment with …

Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …

Performing an effective literature search to obtain the best available evidence is the basis of
any evidence-based discipline, in particular evidence-based medicine. However, with a vast …

RNA splicing is a key mechanism linking genetic variation with psychiatric disorders.
Splicing profiles are particularly diverse in brain and difficult to accurately identify and …