Deciphering lung adenocarcinoma prognosis and immunotherapy response through an AI‐driven stemness‐related gene signature

B Ye, G Hongting, W Zhuang, C Chen… - Journal of Cellular …, 2024 - Wiley Online Library
Lung adenocarcinoma (LUAD) is a leading cause of cancer‐related deaths, and improving
prognostic accuracy is vital for personalised treatment approaches, especially in the context …

Single-cell RNA sequencing of human tissue supports successful drug targets

E Dann, E Teeple, R Elmentaite, KB Meyer, G Gaglia… - MedRxiv, 2024 - medrxiv.org
Early characterization of drug targets associated with disease can greatly reduce clinical
failures attributed to lack of safety or efficacy. As single-cell RNA sequencing (scRNA-seq) of …

From single-cell to spatial transcriptomics: Decoding the glioma stem cell niche and its clinical implications

L Cao, X Lu, X Wang, H Wu, X Miao - Frontiers in Immunology, 2024 - frontiersin.org
Background Gliomas are aggressive brain tumors associated with a poor prognosis. Cancer
stem cells (CSCs) play a significant role in tumor recurrence and resistance to therapy. This …

A developmental cell atlas of the human thyroid gland

H Massalha, MK Trinh, E Armingol, L Tuck, A Predeus… - bioRxiv, 2024 - biorxiv.org
The primary function of the thyroid gland is the synthesis and release of thyroid hormones,
which are essential for health from embryogenesis to adulthood. Thyroid disorders occur …