Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
Molecular complexes of drug combinations: a review of cocrystals, salts, coamorphous systems and amorphous solid dispersions
As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …
combinational therapy has evolved to be an important treatment modality in many disease …
[HTML][HTML] Role of polymers in the physical and chemical stability of amorphous solid dispersion: A case study of carbamazepine
Incorporating the amorphous drug in polymeric components has been demonstrated as a
feasible approach to enhance the bioavailability of poorly water-soluble drugs. The objective …
feasible approach to enhance the bioavailability of poorly water-soluble drugs. The objective …
Quantifying molecular mixing and heterogeneity in pharmaceutical dispersions at sub-100 nm resolution by spin diffusion NMR
Molecular miscibility and homogeneity of amorphous solid dispersions (ASDs) are critical
attributes that impact physicochemical stability, bioavailability, and processability …
attributes that impact physicochemical stability, bioavailability, and processability …
Amorphous drug–polymer salt with high stability under tropical conditions and fast dissolution: the case of clofazimine and poly (acrylic acid)
We report that the stability of amorphous clofazimine (CFZ) against crystallization is vastly
improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry …
improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry …
Implications of Drug–Polymer Interactions on Time–Temperature–Transformation: A Tool to Assess the Crystallization Propensity in Amorphous Solid Dispersions
The critical cooling rate (CRcrit) to prevent drug crystallization during the preparation of
nifedipine amorphous solid dispersions (ASDs) was determined through the time …
nifedipine amorphous solid dispersions (ASDs) was determined through the time …
Recent advances in the application of characterization techniques for studying physical stability of amorphous pharmaceutical solids
Y Wang, Y Wang, J Cheng, H Chen, J Xu, Z Liu, Q Shi… - Crystals, 2021 - mdpi.com
The amorphous form of a drug usually exhibits higher solubility, faster dissolution rate, and
improved oral bioavailability in comparison to its crystalline forms. However, the amorphous …
improved oral bioavailability in comparison to its crystalline forms. However, the amorphous …
Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability
Amorphous solid dispersion (ASD) is a well-established strategy for enhancing the solubility
and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet …
and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet …
Salts, solvates and hydrates of the multi-kinase inhibitor drug pazopanib with hydroxybenzoic acids
The marketed formulation of pazopanib (PAZ) suffers from low and variable bioavailability
because of its poor dissolution rate and photostability issues. The drug falls under …
because of its poor dissolution rate and photostability issues. The drug falls under …
Amorphous drug–polymer salt with high stability under tropical conditions and fast dissolution: the challenging case of lumefantrine-PAA
Abstract Lumefantrine (LMF), a high-mobility and easy-to-crystallize WHO drug for treating
malaria, can form an amorphous salt with poly (acrylic acid)(PAA) that is remarkably stable …
malaria, can form an amorphous salt with poly (acrylic acid)(PAA) that is remarkably stable …