Redox regulation of hexokinases

P Heneberg - Antioxidants & redox signaling, 2019 - liebertpub.com
Significance: Hexokinases are key enzymes that are responsible for the first reaction of
glycolysis, but they also moonlight other cellular processes, including mitochondrial redox …

[HTML][HTML] The non-oxidative degradation of ascorbic acid at physiological conditions

GLW Simpson, BJ Ortwerth - … et biophysica acta (BBA)-Molecular basis of …, 2000 - Elsevier
The degradation of L-ascorbate (AsA) and its primary oxidation products, L-
dehydroascorbate (DHA) and 2, 3-L-diketogulonate (2, 3-DKG) were studied under …

Human red blood cells as a natural flavonoid reservoir

M Fiorani, A Accorsi, O Cantoni - Free radical research, 2003 - Taylor & Francis
Quercetin is rapidly and avidly taken up by human red blood cells (RBC) via a passive
diffusion mechanism, driven by flavonoid binding to haemoglobin and resulting in an almost …

Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells

L Ferrada, K Salazar, F Nualart - Journal of Cellular Physiology, 2019 - Wiley Online Library
For a long time, the effect of vitamin C on cancer cells has been a controversial concept.
From Linus Pauling's studies in 1976, it was proposed that ascorbic acid (AA) could …

Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes

M Fiorani, R De Sanctis, R De Bellis… - Free Radical Biology and …, 2002 - Elsevier
Reduction of extracellular ferricyanide [Fe (CN) 6]− 3 to ferrocyanide by intact cells reflects
the activity of a trans-plasma membrane oxidoreductase that, in human red blood cells …

Quercetin prevents glutathione depletion induced by dehydroascorbic acid in rabbit red blood cells

M Fiorani, R de Sanctis, P Menghinello… - Free Radical …, 2001 - Taylor & Francis
Exposure of rabbit red blood cells to dehydroascorbic acid (DHA) caused a significant
decline in glutathione content which was largely prevented by quercetin, whereas it was …

Dehydroascorbic acid irreversibly inhibits hexokinase activity

M Fiorani, R De Sanctis, F Scarlatti, L Vallorani… - Molecular and Cellular …, 2000 - Springer
The oxidized form of vitamin C (dehydroascorbic acid, DHA) completely and irreversibly
inactivates recombinant human hexokinase type I, in a pseudo-first order fashion. The …

Determination of cellular vitamin C dynamics by HPLC-DAD

T Miyazawa, A Matsumoto, Y Miyahara - Analyst, 2019 - pubs.rsc.org
A redox-sensitive inter-conversion between ascorbic acid (ASC) and its oxidized form
dehydroascorbic acid (DHA) in the intracellular environment has been of exceptional …

Interactions among ascorbate, dehydroascorbate and glucose transport in cultured hippocampal neurons and glia

M Patel, L McIntosh, T Bliss, D Ho, R Sapolsky - Brain research, 2001 - Elsevier
There is an increasing recognition of the damaging role played by oxygen radicals in
mediating necrotic neuronal injury. As such, it becomes important to understand the …

Substrates of hexokinase, glucose-6-phosphate dehydrogenase, and glyceraldehyde-3-phosphate dehydrogenase prevent the inhibitory response induced by …

M Fiorani, R De Sanctis, F Scarlatti, V Stocchi - Archives of biochemistry …, 1998 - Elsevier
Exposure of intact rabbit erythrocytes or erythrocyte lysates to ascorbic acid/FeCl3in a
glucose-free saline promoted a rapid decline in reduced glutathione and this response was …