The key players of the chronic kidney disease-mineral and bone disorders (CKD-MBD) are
calcium, phosphate, PTH, FGF23, and the vitamin D hormonal system. The progressive …

The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Results We included 25 studies to March 31, 2015 with 4770 participants (88% on
hemodialysis). Patients receiving sevelamer had lower all–cause mortality (risk ratio [RR] …

Hyperphosphatemia has consistently been shown to be associated with dismal outcome in a
wide variety of populations, particularly in chronic kidney disease (CKD). Compelling …

Background In patients on maintenance dialysis, cardiovascular mortality risk is remarkably
high, which can be partly explained by severe coronary artery calcification (CAC) …

Maintenance of phosphate balance is essential for life, and mammals have developed a
sophisticated system to regulate phosphate homeostasis over the course of evolution …

Hyperphosphatemia is common in patients with chronic kidney disease and is increasingly
associated with poor clinical outcomes. Current management of hyperphosphatemia with …

Background Hyperphosphatemia necessitates the use of phosphate binders in most dialysis
patients. Long-term efficacy and tolerability of the iron-based phosphate binder, sucroferric …

The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline
Update for the Diagnosis, Evaluation, Prevention, and Treatment of chronic kidney disease …

A series of problems including osteopathy, abnormal serum data, and vascular calcification
associated with chronic kidney disease (CKD) are now collectively called CKD-mineral bone …