Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets
T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …
the origin, course of action and treatment of any disease state is essential. A microscopic …
Enhancer RNAs and regulated transcriptional programs
A large portion of the human genome is transcribed into RNAs without known protein-coding
functions, far outnumbering coding transcription units. Extensive studies of long noncoding …
functions, far outnumbering coding transcription units. Extensive studies of long noncoding …
In vivo single-molecule analysis reveals COOLAIR RNA structural diversity
Cellular RNAs are heterogeneous with respect to their alternative processing and secondary
structures, but the functional importance of this complexity is still poorly understood. A set of …
structures, but the functional importance of this complexity is still poorly understood. A set of …
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin,
but how they target chromatin remains poorly understood. We have used chromatin RNA …
but how they target chromatin remains poorly understood. We have used chromatin RNA …
The RNA Atlas expands the catalog of human non-coding RNAs
Existing compendia of non-coding RNA (ncRNA) are incomplete, in part because they are
derived almost exclusively from small and polyadenylated RNAs. Here we present a more …
derived almost exclusively from small and polyadenylated RNAs. Here we present a more …
[HTML][HTML] The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the
activation state of genes controlling pluripotency, lineage commitment, and cell …
activation state of genes controlling pluripotency, lineage commitment, and cell …
Pan-cancer analysis of lncRNA regulation supports their targeting of cancer genes in each tumor context
Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful
are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate …
are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate …
Transcriptional regulatory functions of nuclear long noncoding RNAs
KW Vance, CP Ponting - Trends in Genetics, 2014 - cell.com
Several nuclear localised intergenic long noncoding RNAs (lncRNAs) have been ascribed
regulatory roles in transcriptional control and their number is growing rapidly. Initially, these …
regulatory roles in transcriptional control and their number is growing rapidly. Initially, these …
LncRNA Khps1 regulates expression of the proto-oncogene SPHK1 via triplex-mediated changes in chromatin structure
A Postepska-Igielska, A Giwojna, L Gasri-Plotnitsky… - Molecular cell, 2015 - cell.com
Although thousands of long noncoding RNAs (lncRNAs) have been discovered, very little is
known about their mode of action. Here we functionally characterize an E2F1-regulated …
known about their mode of action. Here we functionally characterize an E2F1-regulated …
RNA-DNA triplex formation by long noncoding RNAs
Y Li, J Syed, H Sugiyama - Cell chemical biology, 2016 - cell.com
Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological
processes through various mechanisms that are not fully understood. Proposed …
processes through various mechanisms that are not fully understood. Proposed …