[PDF][PDF] Chromaffin cells of the adrenal medulla: physiology, pharmacology, and disease

E Carbone, R Borges, LE Eiden, AG García… - Compr …, 2019 - researchgate.net
Chromaffin cells (CCs) of the adrenal gland and the sympathetic nervous system produce
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …

Calcium channel types contributing to chromaffin cell excitability, exocytosis and endocytosis

S Mahapatra, C Calorio, DHF Vandael, A Marcantoni… - Cell calcium, 2012 - Elsevier
Voltage gated Ca2+ channels are effective voltage sensors of plasma membrane which
convert cell depolarizations into Ca2+ signaling. The chromaffin cells of the adrenal medulla …

Roles of Na+, Ca2+, and K+ channels in the generation of repetitive firing and rhythmic bursting in adrenal chromaffin cells

CJ Lingle, PL Martinez-Espinosa, L Guarina… - … -European Journal of …, 2018 - Springer
Adrenal chromaffin cells (CCs) are the main source of circulating catecholamines (CAs) that
regulate the body response to stress. Release of CAs is controlled neurogenically by the …

Equal sensitivity of Cav1. 2 and Cav1. 3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells

S Mahapatra, A Marcantoni, A Zuccotti… - The Journal of …, 2012 - Wiley Online Library
Key points• Cav1. 2 and Cav1. 3 L‐type calcium channels are highly expressed in rat and
mouse chromaffin cells. Beside shaping and pacemaking action potential trains, they …

Voltage-gated calcium channels (CaV) in GtoPdb v.2023.1

WA Catterall, E Perez-Reyes, TP Snutch… - IUPHAR/BPS Guide …, 2023 - journals.ed.ac.uk
Ca 2+ channels are voltage-gated ion channels present in the membrane of most excitable
cells. The nomenclature for Ca 2+ channels was proposed by [131] and approved by the NC …

[HTML][HTML] Cav1. 3 and Cav1. 2 channels of adrenal chromaffin cells: emerging views on cAMP/cGMP-mediated phosphorylation and role in pacemaking

DHF Vandael, S Mahapatra, C Calorio… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Voltage-gated Ca2+ channels (VGCCs) are voltage sensors that convert membrane
depolarizations into Ca2+ signals. In the chromaffin cells of the adrenal medulla, the Ca2+ …

[HTML][HTML] Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland

A Pérez-Alvarez, A Hernández-Vivanco… - The FASEB …, 2012 - ncbi.nlm.nih.gov
In the present study, we have electrophysiologically characterized native nicotinic
acetylcholine receptors (nAChRs) in human chromaffin cells of the adrenal gland as well as …

[HTML][HTML] Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling

T Mäki-Marttunen, GT Lines, AG Edwards… - Translational …, 2017 - nature.com
Schizophrenia patients have an increased risk of cardiac dysfunction. A possible factor
underlying this comorbidity are the common variants in the large set of genes that have …

Functional Chromaffin Cell Plasticity in Response to Stress: Focus on Nicotinic, Gap Junction, and Voltage-Gated Ca2+ Channels

NC Guérineau, MG Desarménien, V Carabelli… - Journal of Molecular …, 2012 - Springer
An increase in circulating catecholamines constitutes one of the mechanisms whereby
human body responds to stress. In response to chronic stressful situations, the adrenal …

Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study

T Mäki-Marttunen, G Halnes, A Devor, A Witoelar… - Biological Psychiatry …, 2016 - Elsevier
Background Recent genome-wide association studies have identified a large number of
genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters …