Microglia, the brain's immune sentinels, have garnered much attention in recent years.
Researchers have begun to identify the manifold roles that these cells play in the central …

Abstract Colony-stimulating factor-1 receptor (CSF-1R), also known as FMS kinase, is a type
I single transmembrane protein mainly expressed in myeloid cells, such as monocytes …

Microglia harness an unutilized health-promoting potential in age-related
neurodegenerative and neuroinflammatory diseases, conditions like progressive multiple …

The dynamic expansions and contractions of the microglia population in the central nervous
system (CNS) to achieve homeostasis are likely vital for their function. Microglia respond to …

Abstract Although IL-34 and CSF-1 share actions as key mediators of monocytes/
macrophages survival and differentiation, they also display differences that should be …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the
most common form of dementia in the world. Microglia are the innate immune cells of CNS; …

Microglia are widely distributed in the central nervous system (CNS), where they aid in the
maintenance of neuronal function and perform key auxiliary roles in phagocytosis, neural …

Although traditionally seen as regulators of hematopoiesis, colony-stimulating factors (CSFs)
have emerged as important players in the nervous system, both in health and disease. This …

Alzheimer's disease is the most common form of dementia. Notwithstanding the huge
investments in drug development, only one disease-modifying treatment has been recently …

Prion diseases are neurodegenerative diseases that affect humans and animals. They are
always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology …