The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Acute kidney injury (AKI) is defined by a rapid increase in serum creatinine levels, reduced
urine output or both. Death may occur in 16–49% of patients admitted to an intensive care …

Acute myocardial ischemia induces hyperkalemia (accumulation of extracellular potassium),
a major perpetrator of lethal reentrant ventricular arrhythmias. Despite considerable …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Cardiac conduction velocity (CV) is a critical electrophysiological characteristic of the
myocardium, representing the speed at which electrical pulses propagate through cardiac …

Aims Lethal arrhythmias in hypertrophic cardiomyopathy (HCM) are widely attributed to
myocardial ischaemia and fibrosis. How these factors modulate arrhythmic risk remains …

Background and Aim: The sinoatrial node is responsible for the intrinsic electrical activation
that in mammals leads to coordinated rhythmic contractions of the heart, from where it is …

Abstract Background and Objective In silico methods are gaining attention for predicting
drug-induced Torsade de Pointes (TdP) in different stages of drug development. However …

Increased extracellular potassium concentration (hyperkalemia) and electrical alternans in
the action potential (AP) have been shown experimentally to be highly proarrhythmic during …

Increased extracellular potassium concentration (hyperkalemia) and electrical alternans in
the action potential (AP) have been shown experimentally to be highly proarrhythmic during …