Placental lactogen as a marker of maternal obesity, diabetes, and fetal growth abnormalities: current knowledge and clinical perspectives

R Sibiak, M Jankowski, P Gutaj, P Mozdziak… - Journal of Clinical …, 2020 - mdpi.com
Placental lactogen (PL) is a peptide hormone secreted throughout pregnancy by both
animal and human specialized endocrine cells. PL plays an important role in the regulation …

Biochemical tests of placental function versus ultrasound assessment of fetal size for stillbirth and small‐for‐gestational‐age infants

AEP Heazell, DJL Hayes, M Whitworth… - Cochrane Database …, 2019 - cochranelibrary.com
Background Stillbirth affects 2.6 million pregnancies worldwide each year. Whilst the
majority of cases occur in low‐and middle‐income countries, stillbirth remains an important …

[HTML][HTML] Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a stepped wedge, cluster-randomised trial

JE Norman, AEP Heazell, A Rodriguez, CJ Weir… - The Lancet, 2018 - thelancet.com
Background 2· 6 million pregnancies were estimated to have ended in stillbirth in 2015. The
aim of the AFFIRM study was to test the hypothesis that introduction of a reduced fetal …

[HTML][HTML] Placental growth factor as a marker of fetal growth restriction caused by placental dysfunction

SJ Benton, LM McCowan, AEP Heazell, D Grynspan… - Placenta, 2016 - Elsevier
Introduction Discriminating between placentally-mediated fetal growth restriction and
constitutionally-small fetuses is a challenge in obstetric practice. Placental growth factor …

Placental dysfunction underlies increased risk of fetal growth restriction and stillbirth in advanced maternal age women

SC Lean, AEP Heazell, MR Dilworth, TA Mills… - Scientific reports, 2017 - nature.com
Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth
restriction (FGR) and stillbirth. We hypothesised that maternal ageing is associated with …

Hypoxia and oxidative stress induce sterile placental inflammation in vitro

BC Baker, AEP Heazell, C Sibley, R Wright, H Bischof… - Scientific reports, 2021 - nature.com
Fetal growth restriction (FGR) and stillbirth are associated with placental dysfunction and
inflammation and hypoxia, oxidative and nitrative stress are implicated in placental damage …

Plasma miRNA profiles in pregnant women predict infant outcomes following prenatal alcohol exposure

S Balaraman, JJ Schafer, AM Tseng, W Wertelecki… - PLoS …, 2016 - journals.plos.org
Fetal alcohol spectrum disorders (FASD) are difficult to diagnose since many heavily
exposed infants, at risk for intellectual disability, do not exhibit craniofacial dysmorphology or …

Mindfetalness to increase women's awareness of fetal movements and pregnancy outcomes: a cluster‐randomised controlled trial including 39 865 women

A Akselsson, H Lindgren, S Georgsson… - … Journal of Obstetrics …, 2020 - Wiley Online Library
Objective To examine whether a method for raising women's awareness of fetal movements,
Mindfetalness, can affect pregnancy outcomes. Design Cluster‐randomised controlled trial …

Stresses and strains on the human fetal skeleton during development

SW Verbruggen, B Kainz… - Journal of The …, 2018 - royalsocietypublishing.org
Mechanical forces generated by fetal kicks and movements result in stimulation of the fetal
skeleton in the form of stress and strain. This stimulation is known to be critical for prenatal …

Evaluation of pregnancy outcomes among women with decreased fetal movements

JM Turner, V Flenady, D Ellwood, M Coory… - JAMA network …, 2021 - jamanetwork.com
Importance Stillbirth is a devastating pregnancy outcome with far-reaching economic and
psychosocial consequences, but despite significant investment, a screening tool for …