Highlights•Modulation of synaptic strength can occur through changes in short-term
plasticity.•Modulators can shape or induce long-term synaptic plasticity.•Modulators can …

Covering: 2000 to mid-2021 The phosphate ester is a versatile, widespread functional group
involved in a plethora of biological activities. Its presence in secondary metabolites …

The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact
with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in …

Background Cerebral overexcitation needs inhibitory neurons be functionally upregulated to
rebalance excitation vs. inhibition. For example, the intensive activities of GABAergic …

Voltage-gated sodium channels (VGSCs) are important channels which participate in many
physiological functions. Whether VGSCs can be modulated by changes in osmolality in …

Interaction between the entorhinal cortex (EC) and basolateral amygdala (BLA) may be a
fundamental component in the consolidation of many forms of affective memory, such as …

The contribution of striatal protein kinase C (PKC) isoform changes in levodopa (L-DOPA)
induced motor response complications in parkinsonian rats was investigated and the ability …

In non-excitable cells, the inositol 1, 4, 5-trisphosphate receptor (IP3R) is an intracellular
Ca2+ channel which plays a major role in Ca2+ signalling. Three isoforms of IP3R have …

Strong experimental evidence indicates that protein kinase and phosphatase (KP) cycles
are critical to both the induction and maintenance of activity-dependent modifications in …

The histamine H 3 receptor (H 3 R) is abundantly expressed in the Central Nervous System
where it regulates several functions pre and postsynaptically. H 3 Rs couple to Gα i/o …