COX-2 in liver fibrosis
H Yang, Y Xuefeng, W Shandong, X Jianhua - Clinica chimica acta, 2020 - Elsevier
As a vital inducible sensor, cyclooxygenase-2 (COX-2) plays an important role in the
progress of hepatic fibrogenesis. Activation of hepatic stellate cells (HSCs) in the liver can …
progress of hepatic fibrogenesis. Activation of hepatic stellate cells (HSCs) in the liver can …
Network pharmacology and in vivo experiments reveal the pharmacological effects and molecular mechanisms of Simiao Powder in prevention and treatment for gout
H Xu, J Wu, S Wang, L Xu, P Liu, Y Shi, S Wu… - … medicine and therapies, 2022 - Springer
Background Gout is a common disease with high incidence due to unhealthy diet and living
habits. Simiao Powder, as a classic formula consisted of four common herbs, has been …
habits. Simiao Powder, as a classic formula consisted of four common herbs, has been …
Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core
M Dvorakova, L Langhansova, V Temml… - ACS medicinal …, 2021 - ACS Publications
Selective cyclooxygenase-1 (COX-1) inhibition has got into the spotlight with the discovery
of COX-1 upregulation in various cancers and the cardioprotective role of COX-1 in control …
of COX-1 upregulation in various cancers and the cardioprotective role of COX-1 in control …
Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines
A new series of thieno [2, 3-d] pyrimidine derivatives 4, 5, 6a-o, and 11 was designed and
synthesized starting from cyclohexanone under Gewald condition with the aim to develop …
synthesized starting from cyclohexanone under Gewald condition with the aim to develop …
Bioactive substances inhibiting COX-2 and cancer cells isolated from the fibrous roots of Alangium chinense (Lour.) Harms
T Xiao, X Cheng, J Huang, Z Guo, L Tao, X Shen - RSC advances, 2023 - pubs.rsc.org
Alangium chinense has been used as a traditional folk medicine for centuries to treat
rheumatism, skin diseases, and diabetes by the people of Southeast Asia. However, the …
rheumatism, skin diseases, and diabetes by the people of Southeast Asia. However, the …
[HTML][HTML] Spike lavender essential oil attenuates hyperuricemia and induced renal injury by modulating the TLR4/NF-κB/NLRP3 signalling pathway
P Zhou, B Zhang, X Wang, J Duan, J Li, J Wang… - Arabian Journal of …, 2024 - Elsevier
Hyperuricemia (HUA), recognized as the fourth “high” condition following hypertension,
hyperlipidemia, and hyperglycemia, is a metabolic disorder that severely impairs renal …
hyperlipidemia, and hyperglycemia, is a metabolic disorder that severely impairs renal …
1, 4-dihydroquinazolin-3 (2h)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, cox-1/2 …
A Sakr, H Kothayer, SM Ibrahim, MM Baraka… - Bioorganic Chemistry, 2019 - Elsevier
The design and synthesis of a new series of 1, 4-dihydroquinazolin-3 (2H)-yl benzamide
derivatives (4a–o) as anti-inflammatory and analgesic agents and COX-1/2 inhibitors are …
derivatives (4a–o) as anti-inflammatory and analgesic agents and COX-1/2 inhibitors are …
Traditional Chinese medicine Aconiti radix Cocta improves rheumatoid arthritis via suppressing COX‐1 and COX‐2
S Li, R Li, YX Xu, JPA Baak, JH Gao… - Evidence‐Based …, 2021 - Wiley Online Library
According to Traditional Chinese Medicine (TCM), Aconiti Radix Cocta (AC) is clinically
employed to expel wind, remove dampness, and relieve pain. We evaluated the …
employed to expel wind, remove dampness, and relieve pain. We evaluated the …
Signaling pathways mediating bradykinin-induced contraction in murine and human detrusor muscle
K Borsodi, H Balla, PJ Molnár, Á Lénárt… - Frontiers in …, 2022 - frontiersin.org
Bradykinin (BK) has been proposed to modulate urinary bladder functions and implicated in
the pathophysiology of detrusor overactivity. The present study aims to elucidate the …
the pathophysiology of detrusor overactivity. The present study aims to elucidate the …
Design, Synthesis and bioevaluation of highly functionalized 1, 2, 3-triazole-guanidine conjugates as anti-inflammatory and antioxidant agents
MA Siddiqui, AA Nagargoje, MH Shaikh… - Polycyclic Aromatic …, 2023 - Taylor & Francis
In search of new biologically potent molecules a small focused library of new guanidine-1, 2,
3-triazole hybrid derivatives were synthesized via Organocatalytic enolate-mediated azide …
3-triazole hybrid derivatives were synthesized via Organocatalytic enolate-mediated azide …